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The role of chromosome positioning in gene regulation and chromosome stability is fueling a growing interest in technologies that reveal the in situ organization of the genome.
Among these technologies are chromosome conformation capture (3C) (1) and its several iterations, such as Hi-C (2), which are applied to populations of nuclei to identify chromosomal regions that are in close proximity to each other (3, 4).
Nine of these lnc RNAs (CDKN2B-AS1/ANRIL, EGOT, H19, HOTAIR, LOC285194/TUSC7, RMRP, RNY5, SOX2-OT and SRA1) were also confirmed in end-stage failing hearts.Some authors may elect to put a 1-year to 5-year renewable embargo on access; full text for those will not be available during the term of the embargo.There are public-accessible copies of some dissertations archived in various other series within the UNL Digital Commons.Further validations were performed in left ventricle samples derived from explanted hearts of end-stage heart failure patients and in a mouse model of cardiac hypertrophy, obtained by transverse aortic constriction.Peripheral blood mononuclear cells of heart failure patients were also analyzed.