A spokesperson for Bush confirmed the split, but offered no further details on the relationship between the couple, who star together on One Tree Hill.
"This is a difficult and unfortunate situation," said Bush in a statement.
He is known for portraying Lucas Scott in The WB/CW teen drama series One Tree Hill from 2003 to 2009, war veteran and SSR agent Jack Thompson in the Marvel/ABC series Agent Carter, and also had starring roles in the films Freaky Friday (2003), A Cinderella Story (2004), and House of Wax (2005).
Popular among teenagers and young adults in the early 2000s, Murray was born in Buffalo, New York.
True confessions: Sophia Bush spoke of reconciling her personal and professional lives while co-starring with her ex-husband on One Tree Hill on Watch What Happens Live with Andy Cohen on Monday night Rumours surfaced that Chad, 32, allegedly 'cheated on Sophia with Paris Hilton', his co-star in horror film House Of Wax, according to multiple reports including Us Weekly, which neither party has discussed.
"Matt has been a wonderful second chapter for me because Chad and I had done everything together until I was 27 years old, and that was a lot of work.
Murray portrayed the role Charlie Todd on the successful television series Dawson's Creek in 2001.
Most likely chad Michael Murray and hilarie Burton will return as guest stars or maybe return to the show.
So to come back and have this new love interest that I have really wonderful chemistry with and who I really love as a person has been nice." Will Burton have to say goodbye to her new leading man anytime soon? "I consider 'White Collar' my home base," Bomer said.
"I’m so lucky to get to play a character that’s very multifaceted and the writers take risks on and never get into a staid process with.