Biostatics and Biomathematics Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2-B500, Seattle, WA 98109 (M. Selecting one or more controls that are matched to each case on factors such as age, co-morbidities or study site improves study validity by eliminating potential biases due to differential characteristics of readings for cases versus controls.
F.); Department of Biostatistics, University of Washington, Health Sciences Building, Suite F-600, Seattle, WA 98195 (M. P); Departments of Critical Care and Emergency Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, University of Pittsburgh, Pittsburgh, PA (CWS)Studies evaluating a new diagnostic imaging test may select control subjects without disease who are similar to case subjects with disease in regards to factors potentially related to the imaging result.
However, it is not widely appreciated that valid analysis requires that the receiver operating characteristic (ROC) curve be adjusted for covariates.
We propose a new computationally simple method for estimating the covariate-adjusted ROC curve that is appropriate in matched case-control studies.
We provide theoretical arguments for the validity of the estimator and demonstrate its application to data.
To do so, you click the hyperlink "Save residuals" in the results window.The new estimator is computationally very simple, yet we show it yields values that approximate the existing, more complicated estimator in simulated data sets.We found that the new estimator has excellent statistical properties, with bias and efficiency comparable with the existing method.An investigation of the relationship between income-status and future alumni involvement Leibovitch, Abigail (2013) Theory of mind and the ability to make emotional inferences among children with high-functioning Autism Spectrum Disorders Lein, Max J (2013) Droplet-Interface Bilayer Technologies for Membrane Protein Analysis and Molecular Trafficking Measurements Leonard, Nathaniel C (2013) The Reflexive Scaffold: Metatheatricality, Genre, and Cultural Performance in English Renaissance Drama Levy, Yariv Z (2013) Multiscale modeling of human addiction: A computational hypothesis for allostasis and healing Lewis, Quentin (2013) An archaeology of improvement in rural New England: Capitalism, landscape change, and rural life in the early 19th century Li, Chao (2013) Optimizing linear queries under differential privacy Li, Chengbei (2013) Determination of arsenic in water by potentially portable methodology Lie, Sunny (2013) Beholders of the truth, pre-destined to be saved: the communication of Chinese indonesian reformed evangelical Christian (cirec) identity Li, Houbao (2013) Geochemistry and inorganic carbon transport of a glacial till drumlin at a road salt facility Li, Jingran (2013) Conditional Gaussian fluctuations and refined asymptotics of the spin in the phase-coexistence region Lin, Ken-Hou (2013) The rise of finance and growing inequality Lin, Yenhan (2013) Stability of thin liquid films flowing over heterogeneous surfaces and gas-solid flow of decomposing particles with applications to biomass pyrolysis Mac Donald, Daniel P (2013) Contract as contested terrain: An economic history of law and the rise of American Capitalism Mackay, Patricia E (2013) The effects of tools of the mind on math and reading scores in kindergarten Maddikeri, Raghavendra Raj (2013) Characterization of self-assembled functional polymeric nanostructures: I. Zwitterionic polymer vesicles in ionic liquid Mahalik, Jyoti Prakash (2013) Computer simulation of viral-assembly and translocation Maher, Kathryn N (2013) A novel approach for stable, cell-type restricted knockdown of gene expression in C.elegans Mao, Yingyi (2013) Designing novel emulsion performance by controlled hetero-aggregation of mixed biopolymer systems Marchesi, Milena (2013) Contested subjects: Biopolitics & the moral stakes of social cohesion in post-welfare Italy Marino, Michella M (2013) Sweating femininity: Women athletes, masculine culture, and American inequality from 1930 to the present Martel, Philippe Paul (2013) Measuring proton spin polarizabilities with polarized compton scattering Masoumi, Amirhossein (2013) Supply chain management of perishable products with applications to healthcare Massoni, Shawn Christopher (2013) Rec A dynamics & the SOS response in Escherichia coli: Cellular limitation of inducing filaments Matarazzo, Stacey Ann (2013) Knuckle-walking signal in the manual phalanges and metacarpals of the great apes (Pan and Gorilla) Mc Carthy, Jennifer Lynn (2013) Conservation and ecology of four sympatric felid species in Bukit Barisan Selatan National Park, Sumatra, Indonesia Mc Ennis, Kathleen (2013) Particle behavior on anisotropically curved interfaces Mc Henry, Kristen Abatsis (2013) Promising prevention: Greening the breast cancer movement in the United States Mc Manus Scircle, Melissa (2013) Visiting or here to stay?